| The hypoglycemic (blood sugar-lowering)
effect of gymnema leaves was first documented in the late 1920s.
This action is gradual in nature, differing from the rapid effect
of many prescription hypo-glycemic drugs.
Gymnema leaves raise insulin levels, according to research
in healthy volunteers. The leaves are also noted for lowering
serum cholesterol and triglycerides. While studies have shown
that a water-soluble acidic fraction of the leaves provides
hypoglycemic actions, it is not yet clear what specific constituent
in the leaves is responsible for this action.
Some researchers have suggested gymnemic acid as one possible
candidates Further research is needed to clearly determine
which constituent is responsible for this effect. Gurmarin,
another constituent of the leaves, and gymnemic acid have
been shown to block sweet taste in humans.
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